概述

  • 产品名称Anti-Factor V抗体
    参阅全部 Factor V 一抗
  • 描述
    小鼠单克隆抗体to Factor V
  • 特异性This antibody recognizes bovine factor V, an epitope on the 120,000 activation peptide of bovine factor V.
  • 经测试应用适用于: WB, ELISA, RIAmore details
  • 种属反应性
    与反应: Cow
  • 免疫原

    Full length native purified Cow Factor V

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 50% (v/v)Glycerol/water
  • Concentration information loading...
  • 纯度Ion Exchange Chromatography
  • 纯化说明Salt fractionation followed by gel filtration and ion exchange chromatography.
  • 克隆单克隆
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab61349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 252 kDa.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

靶标

  • 功能Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • 组织特异性Plasma.
  • 疾病相关Factor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1
  • 序列相似性Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.
  • 结构域Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
  • 翻译后修饰Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.
  • 细胞定位Secreted.
  • Information by UniProt
  • 别名
    • Activated protein C cofactor antibody
    • APC cofactor antibody
    • coagulation factor V (proaccelerin, labile factor) antibody
    • Coagulation factor V antibody
    • coagulation factor V jinjiang A2 domain antibody
    • Coagulation factor V light chain antibody
    • F5 antibody
    • FA5_HUMAN antibody
    • Factor V Leiden antibody
    • FactorV antibody
    • FVL antibody
    • Labile factor antibody
    • PCCF antibody
    • Proaccelerin antibody
    • proaccelerin, labile factor antibody
    • Protein C cofactor antibody
    • RPRGL1 antibody
    • THPH2 antibody
    see all

Anti-Factor V antibody (ab61349)参考文献

ab61349 has not yet been referenced specifically in any publications.

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