概述

  • 产品名称Anti-Factor V抗体
    参阅全部 Factor V 一抗
  • 描述
    羊多克隆抗体to Factor V
  • 经测试应用适用于: ELISA, WB, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human Factor V

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: None
    Constituents: 50% Glycerol, HEPES-buffered saline, pH 7.5
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab30905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
WB Use at an assay dependent concentration.
IP Use at an assay dependent concentration.

靶标

  • 功能Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • 组织特异性Plasma.
  • 疾病相关Factor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1
  • 序列相似性Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.
  • 结构域Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
  • 翻译后修饰Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activated protein C cofactor antibody
    • APC cofactor antibody
    • coagulation factor V (proaccelerin, labile factor) antibody
    • Coagulation factor V antibody
    • coagulation factor V jinjiang A2 domain antibody
    • Coagulation factor V light chain antibody
    • F5 antibody
    • FA5_HUMAN antibody
    • Factor V Leiden antibody
    • FactorV antibody
    • FVL antibody
    • Labile factor antibody
    • PCCF antibody
    • Proaccelerin antibody
    • proaccelerin, labile factor antibody
    • Protein C cofactor antibody
    • RPRGL1 antibody
    • THPH2 antibody
    see all

Anti-Factor V antibody (ab30905)参考文献

ab30905 has not yet been referenced specifically in any publications.

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