Anti-Factor IX抗体[13F42-F6] (ab125149)

概述

  • 产品名称Anti-Factor IX抗体[13F42-F6]
    参阅全部 Factor IX 一抗
  • 描述
    小鼠单克隆抗体[13F42-F6] to Factor IX
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length purified native Human Factor IX protein.

  • 阳性对照
    • Human Liver tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab125149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 52 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ELISA Use at an assay dependent concentration.

靶标

  • 功能Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
  • 组织特异性Synthesized primarily in the liver and secreted in plasma.
  • 疾病相关Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
    Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
    Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 结构域Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
  • 翻译后修饰Activated by factor XIa, which excises the activation peptide.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Christmas Disease antibody
    • Christmas factor antibody
    • Coagulant factor IX antibody
    • Coagulation factor 9 antibody
    • Coagulation factor IX antibody
    • Coagulation factor IXa heavy chain antibody
    • F9 antibody
    • FA9_HUMAN antibody
    • Factor 9 antibody
    • Factor IX Deficiency antibody
    • FactorIX antibody
    • FIX antibody
    • Haemophilia B antibody
    • HEMB antibody
    • MGC129641 antibody
    • MGC129642 antibody
    • P19 antibody
    • Plasma Thromboplastic Component antibody
    • Plasma thromboplastin component antibody
    • PTC antibody
    see all

Anti-Factor IX antibody [13F42-F6] 图像

  • ab125149, at 10µg/ml, staining Factor IX in formalin-fixed, paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-Factor IX antibody [13F42-F6] (ab125149)参考文献

ab125149 has not yet been referenced specifically in any publications.

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