HRP Anti-Factor B抗体[KT24] (ab106687)
Key features and details
- HRP Mouse monoclonal [KT24] to Factor B
- Suitable for: Sandwich ELISA
- Reacts with: Human
- Conjugation: HRP
- Isotype: IgG1
概述
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产品名称
HRP Anti-Factor B抗体[KT24]
参阅全部 Factor B 一抗 -
描述
HRP小鼠单克隆抗体[KT24] to Factor B -
宿主
Mouse -
偶联物
HRP -
经测试应用
适用于: Sandwich ELISAmore details -
种属反应性
与反应: Human -
免疫原
Purified Human Factor B from Human blood.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
Preservative: 0.01% Thimerosal (merthiolate)
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
KT24 -
同种型
IgG1 -
研究领域
相关产品
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Related Products
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-
sELISA pair antibody
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106687于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Sandwich ELISA |
1/1000. Can be paired for Sandwich ELISA with Mouse monoclonal [KT21] to Factor B (ab110651).
as Detection antibody. |
说明 |
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Sandwich ELISA
1/1000. Can be paired for Sandwich ELISA with Mouse monoclonal [KT21] to Factor B (ab110651). as Detection antibody. |
靶标
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功能
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. -
疾病相关
Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:612924]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. -
序列相似性
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 3 Sushi (CCP/SCR) domains.
Contains 1 VWFA domain. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 629 Human
- Omim: 138470 Human
- SwissProt: P00751 Human
- Unigene: 69771 Human
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别名
- AHUS4 antibody
- B factor properdin antibody
- BF antibody
see all
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab106687 尚未被引用在任何文献中。