Anti-Factor B抗体[KT21] (ab110651)

概述

  • 产品名称
    Anti-Factor B抗体[KT21]
    参阅全部 Factor B 一抗
  • 描述
    小鼠单克隆抗体[KT21] to Factor B
  • 经测试应用
    适用于: Sandwich ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified Factor B from Human blood

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.1% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 克隆
    单克隆
  • 克隆编号
    KT21
  • 同种型
    IgG2b
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab110651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA Use a concentration of 5 µg/ml. Can be paired for Sandwich ELISA with Mouse monoclonal [KT24] to Factor B (HRP) (ab106687). as the detection antibody.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 86 kDa.

靶标

  • 功能
    Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
  • 疾病相关
    Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:612924]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
  • 序列相似性
    Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
    Contains 3 Sushi (CCP/SCR) domains.
    Contains 1 VWFA domain.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AHUS4 antibody
    • B factor properdin antibody
    • BF antibody
    • BFD antibody
    • C3 proaccelerator antibody
    • C3 proactivator antibody
    • C3/C5 convertase antibody
    • CFAB antibody
    • CFAB_HUMAN antibody
    • CFB antibody
    • Complement Factor B antibody
    • Complement factor B Bb fragment antibody
    • FB antibody
    • FBI12 antibody
    • GBG antibody
    • Glycine rich beta glycoprotein antibody
    • Glycine-rich beta glycoprotein antibody
    • H2 Bf antibody
    • H2BF antibody
    • PBF2 antibody
    • Properdin factor B antibody
    see all

Anti-Factor B antibody [KT21] 图像

  • Sandwich ELISA using ab110651 coated plate and HRP conjugated ab106687 for detection.

实验方案

Anti-Factor B antibody [KT21] (ab110651)参考文献

ab110651 has not yet been referenced specifically in any publications.

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