概述

  • 产品名称Anti-FACL4抗体
    参阅全部 FACL4 一抗
  • 描述
    山羊多克隆抗体to FACL4
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide: C-

    HYLKDIERMYGGK

    , corresponding to C terminal amino acids 699-711 of Human FACL4

  • 阳性对照
    • Human brain (cortex) tissue, Human small intestine tissue, HepG2 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab110007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 79 kDa.
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
  • 疾病相关Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63) [MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
    Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]. A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis.
  • 序列相似性Belongs to the ATP-dependent AMP-binding enzyme family.
  • 细胞定位Mitochondrion outer membrane. Peroxisome membrane. Microsome membrane. Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ACS 4 antibody
    • ACS4 antibody
    • ACSL 4 antibody
    • Acsl4 antibody
    • ACSL4_HUMAN antibody
    • acyl CoA synthetase 4 antibody
    • Acyl CoA synthetase long chain family member 4 antibody
    • FACL 4 antibody
    • FACL4 antibody
    • Fatty acid Coenzyme A ligase antibody
    • fatty acid Coenzyme A ligase long-chain 4 antibody
    • LACS 4 antibody
    • LACS4 antibody
    • Lignoceroyl CoA synthase antibody
    • Long chain 4 antibody
    • long chain acyl CoA synthetase 4 antibody
    • long chain fatty acid CoA ligase 4 antibody
    • long chain fatty acid Coenzyme A ligase 4 antibody
    • Long-chain acyl-CoA synthetase 4 antibody
    • Long-chain-fatty-acid--CoA ligase 4 antibody
    • MRX63 antibody
    • MRX68 antibody
    see all

Anti-FACL4 antibody 图像

  • ab110007, at 3.75 µg/ml, staining FACL4 in human brain (cortex) tissue by immunohistochemistry.
  • ab110007, at 3.75 µg/ml, staining FACL4 in Human small intestine tissue by immunohistochemistry.
  • Anti-FACL4 antibody (ab110007) at 0.1 µg/ml + HepG2 cell lysate in RIPA buffer at 35 µg

    Predicted band size : 79 kDa

Anti-FACL4 antibody (ab110007)参考文献

This product has been referenced in:
  • Lynes EM  et al. Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling. J Cell Sci 126:3893-903 (2013). Read more (PubMed: 23843619) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"