功能Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
组织特异性Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.
序列相似性Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
结构域Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
细胞定位Cytoplasm and Cytoplasm. Localized close to nucleus on the apical side of both normal and neoplastic cells.