概述
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产品名称Anti-FA2H抗体
参阅全部 FA2H 一抗 -
描述兔多克隆抗体to FA2H
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经测试应用适用于: WBmore details
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种属反应性与反应: Mouse
预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
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免疫原
Synthetic peptide corresponding to a region within C-terminal amino acids 257-306 (HGQHHKAPFD GSRLVFPPVP ASLVIAFFYV FLRLILPETV GGIIFAGGLL) of Mouse FA2H (NP_835187).
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阳性对照
- Mouse liver lysate
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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存储溶液Constituents: PBS, 2% Sucrose
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Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
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Positive Controls
应用
Our Abpromise guarantee covers the use of ab111554 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 43 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T. |
靶标
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功能Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids.
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组织特异性Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney.
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疾病相关Defects in FA2H are the cause of leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia (DLDSP) [MIM:612443]. The disorder consists of a progressive neurologic disease manifested by spasticity, disordered tonicity of muscle, and white matter degeneration.
Defects in FA2H are a cause of spastic paraplegia autosomal recessive type 35 (SPG35) [MIM:612319]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. -
序列相似性Belongs to the sterol desaturase family. SCS7 subfamily.
Contains 1 cytochrome b5 heme-binding domain. -
结构域The histidine box domains may contain the active site and/or be involved in metal ion binding.
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细胞定位Endoplasmic reticulum membrane. Microsome membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 338521 Mouse
- Entrez Gene: 307855 Rat
- SwissProt: Q5MPP0 Mouse
- SwissProt: Q2LAM0 Rat
- Unigene: 41083 Mouse
- Unigene: 67886 Rat
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别名
- FA2H antibody
- FA2H_HUMAN antibody
- FAAH antibody
see all
Anti-FA2H antibody 图像
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Western blot - FA2H antibody (ab111554)Anti-FA2H antibody (ab111554) at 1 µg/ml + Mouse liver lysate at 10 µg
Predicted band size : 43 kDa
Anti-FA2H antibody (ab111554)参考文献
ab111554 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"