Anti-FA2H抗体(ab111554)

概述

• 产品名称Anti-FA2H抗体
  参阅全部 FA2H 一抗
• 描述
  兔多克隆抗体to FA2H
• 经测试应用适用于: WBmore details
• 种属反应性
  与反应: Mouse
  预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
• 免疫原

  Synthetic peptide corresponding to a region within C-terminal amino acids 257-306 (HGQHHKAPFD GSRLVFPPVP ASLVIAFFYV FLRLILPETV GGIIFAGGLL) of Mouse FA2H (NP_835187).

  Run BLAST with Run BLAST with
• 阳性对照
  • Mouse liver lysate

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• 存储溶液Constituents: PBS, 2% Sucrose
• Concentration information loading...
• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Tags & Cell Markers
  • Cell Type Markers
  • Epi / Endo-thelial

  • Neuroscience
  • Cell Type Marker
  • Neuron marker
  • Axon marker

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Mouse liver tissue lysate - total protein (ab29301)

应用

靶标

• 功能Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids.
• 组织特异性Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney.
• 疾病相关Defects in FA2H are the cause of leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia (DLDSP) [MIM:612443]. The disorder consists of a progressive neurologic disease manifested by spasticity, disordered tonicity of muscle, and white matter degeneration.
  Defects in FA2H are a cause of spastic paraplegia autosomal recessive type 35 (SPG35) [MIM:612319]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
• 序列相似性Belongs to the sterol desaturase family. SCS7 subfamily.
  Contains 1 cytochrome b5 heme-binding domain.
• 结构域The histidine box domains may contain the active site and/or be involved in metal ion binding.
• 细胞定位Endoplasmic reticulum membrane. Microsome membrane.

• Target information above from: UniProt accession Q7L5A8 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 338521 Mouse
  • Entrez Gene: 307855 Rat
  • SwissProt: Q5MPP0 Mouse
  • SwissProt: Q2LAM0 Rat
  • Unigene: 41083 Mouse
  • Unigene: 67886 Rat
• 别名
  • FA2H antibody
  • FA2H_HUMAN antibody
  • FAAH antibody

  • FAH1 antibody
  • Fatty acid 2 hydroxylase antibody
  • Fatty acid 2-hydroxylase antibody
  • Fatty acid alpha hydroxylase antibody
  • Fatty acid alpha-hydroxylase antibody
  • Fatty acid hydroxylase domain containing 1 antibody
  • FAXDC1 antibody
  • FLJ25287 antibody
  • SCS7 antibody
  • Spastic paraplegia 35 (autosomal recessive) antibody
  • SPG35 antibody

  see all