Anti-F Box G - Domain 3抗体(ab90143)

概述

  • 产品名称
    Anti-F Box G - Domain 3抗体
    参阅全部 F Box G - Domain 3 一抗
  • 描述
    兔多克隆抗体to F Box G - Domain 3
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (CCYVSRRLSQ LSSHDPLWRR HCKKYWLISE EEKTQKNQCW KSLFIDTYSD) of Human FF Box G – Domain 3 protein (NP_208385).

  • 阳性对照
    • Human fetal small intestine lysate

性能

应用

Our Abpromise guarantee covers the use of ab90143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
  • 序列相似性
    Contains 1 apaG domain.
    Contains 1 F-box domain.
  • 细胞定位
    Nucleus. Colocalizes with PML at the peripheries of nuclear bodies.
  • Information by UniProt
  • 数据库链接
  • 别名
    • F box only protein 3 antibody
    • F box protein 3 antibody
    • F box protein FBX3 antibody
    • F-box only protein 3 antibody
    • FBA antibody
    • FBX3 antibody
    • FBX3_HUMAN antibody
    • FBXO3 antibody
    see all

图片

  • Anti-F Box G - Domain 3 antibody (ab90143) at 1 µg/ml + Human fetal small intestine lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 55 kDa

实验方案

文献

ab90143 has not yet been referenced specifically in any publications.

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