Anti-Ezrin / Radixin / Moesin抗体(ab118572)

概述

  • 产品名称Anti-Ezrin / Radixin / Moesin抗体
  • 描述
    兔多克隆抗体to Ezrin / Radixin / Moesin
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region near the C terminus of Human Ezrin/ Radixin/ Moesin.

  • 阳性对照
    • Human Breast tissue and Mouse NIH-3T3 cells.

性能

应用

Our Abpromise guarantee covers the use of ab118572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 68 kDa.
ELISA 1/20000.
IHC-P Use a concentration of 10 µg/ml.

靶标

  • 相关性Ezrin is a cytoplasmic peripheral membrane protein and functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.
  • 细胞定位Cell Membrane, Cytoskeleton and Cytoplasmic
  • 数据库链接
  • 别名
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Anti-Ezrin / Radixin / Moesin antibody 图像

  • ab118572, at 10 µg/ml, staining Ezrin / Radixin / Moesin in formalin-fixed, paraffin-embedded Human Breast tissue by Immunohistochemistry.
  • All lanes : Anti-Ezrin / Radixin / Moesin antibody (ab118572) at 1/500 dilution

    Lane 1 : NIH-3T3 cell extract without the synthesized peptide.
    Lane 2 : NIH-3T3 cell extract with the synthesized peptide.


    Predicted band size : 68 kDa

Anti-Ezrin / Radixin / Moesin antibody (ab118572)参考文献

ab118572 has not yet been referenced specifically in any publications.

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