概述

  • 产品名称Anti-EZH1抗体
    参阅全部 EZH1 一抗
  • 描述
    山羊多克隆抗体to EZH1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow
  • 免疫原

    Synthetic peptide:

    EIPNPPTSKCITY

    , corresponding to amino acids 2-14 of Human EZH 1.

  • 阳性对照
    • MOLT 4 lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab3670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 - 6 µg/ml. Detects a band of approximately 85 kDa (predicted molecular weight: 85 kDa).Can be blocked with Human EZH1 peptide (ab22954).

靶标

  • 功能Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
  • 序列相似性Belongs to the histone-lysine methyltransferase family. EZ subfamily.
    Contains 1 SET domain.
  • 细胞定位Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Enhancer of zeste homolog 1 (Drosophila) antibody
    • Enhancer of zeste homolog 1 antibody
    • ENX-2 antibody
    • ENX2 antibody
    • Ezh1 antibody
    • EZH1_HUMAN antibody
    • Histone-lysine N-methyltransferase EZH1 antibody
    see all

Anti-EZH1 antibody 图像

  • Anti-EZH1 antibody (ab3670) at 2 µg/ml + MOLT4 cell lysate (in RIPA buffer) at 35 µg

    Predicted band size : 85 kDa
    Observed band size : 85 kDa

Anti-EZH1 antibody (ab3670)参考文献

ab3670 has not yet been referenced specifically in any publications.

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