本 快线抗体 仍未被充份测试和鉴定, 不在质保范围内, 具体请参见 使用条款及细节

概述

  • 产品名称
    Anti-EYA4抗体- Aminoterminal end
    参阅全部 EYA4 一抗
  • 描述
    山羊多克隆抗体to EYA4 - Aminoterminal end

    该产品是 快线抗体，通过亲和纯化得到。对抗原肽有高灵敏度及特异性（ELISA测试）。 Read the terms of use »

  • 宿主
    Goat
  • 特异性
    This antibody is expected to recognise isoforms a, c and d (NP_004091.2, NP_742102.1 and NP_742103.1 respectively).
  • 种属反应性

    预测可用于: Mouse, Human
  • 免疫原

    Synthetic peptide:

    EDSQDLNEQSVKKTC

    , corresponding to N terminal amino acids 2-16 of Human EYA4

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

性能

应用

  • 应用说明
    This antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:128,000.

    Western Blot: Preliminary experiments gave an approx 50kDa band in Human and Mouse Brain lysates and in Pituitary Mouse cell line NIH 3T3 after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated sizes of 69.5kDa, 67.1kDa and 69.4kDa according to NP_004091.2, NP_742102.1 and NP_742103.1 respectively. The 50kDa band was successfully blocked by incubation with the immunizing peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • 靶标

    • 功能
      Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
    • 组织特异性
      Highly expressed in heart and skeletal muscle.
    • 疾病相关
      Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
      Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    • 序列相似性
      Belongs to the HAD-like hydrolase superfamily. EYA family.
    • 细胞定位
      Cytoplasm. Nucleus.
    • Information by UniProt
    • 数据库链接
      • 别名
        • CMD1J antibody
        • Deafness, autosomal dominant 10 antibody
        • DFNA 10 antibody
        • DFNA10 antibody
        • dJ78N10.1 (eyes absent (Drosophila) homolog 4) antibody
        • dJ78N10.1 (eyes absent) antibody
        • EYA 4 antibody
        • eya4 antibody
        • EYA4_HUMAN antibody
        • Eyes absent 4 antibody
        • Eyes absent homolog 4 (Drosophila) antibody
        • Eyes absent homolog 4 antibody
        • HGNC:3522 antibody
        • OTTHUMP00000040267 antibody
        see all

      文献

      This product has been referenced in:
      • Huang S  et al. Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21) Acute Myeloid Leukemia. Chin Med J (Engl) 129:1355-62 (2016). WB . Read more (PubMed: 27231175) »

      See 1 Publication for this product

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