Anti-EYA4抗体- Aminoterminal end (ab47990)

概述

• 产品名称
  Anti-EYA4抗体- Aminoterminal end
  参阅全部 EYA4 一抗
• 描述
  山羊多克隆抗体to EYA4 - Aminoterminal end

  This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

• 特异性
  This antibody is expected to recognise isoforms a, c and d (NP_004091.2, NP_742102.1 and NP_742103.1 respectively).
• 种属反应性
  
  预测可用于: Mouse, Human
• 免疫原

  Synthetic peptide:

  EDSQDLNEQSVKKTC

  , corresponding to N terminal amino acids 2-16 of Human EYA4

  Run BLAST with Run BLAST with

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris saline, pH 7.3
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 纯化说明
  Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Neuroscience
  • Sensory System
  • Visual system

  • Neuroscience
  • Sensory System
  • Auditory system

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Co-factors

  • Cardiovascular
  • Heart
  • Hypertrophy
  • Transcription factors

相关产品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

应用

靶标

• 功能
  Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
• 组织特异性
  Highly expressed in heart and skeletal muscle.
• 疾病相关
  Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
• 序列相似性
  Belongs to the HAD-like hydrolase superfamily. EYA family.
• 细胞定位
  Cytoplasm. Nucleus.

• Target information above from: UniProt accession O95677 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 2070 Human
  • Entrez Gene: 14051 Mouse
  • Omim: 603550 Human
  • SwissProt: O95677 Human
  • SwissProt: Q9Z191 Mouse
  • Unigene: 596680 Human
  • Unigene: 332128 Mouse
  • Unigene: 446298 Mouse
• 别名
  • CMD1J antibody
  • Deafness, autosomal dominant 10 antibody
  • DFNA 10 antibody

  • DFNA10 antibody
  • dJ78N10.1 (eyes absent (Drosophila) homolog 4) antibody
  • dJ78N10.1 (eyes absent) antibody
  • EYA 4 antibody
  • eya4 antibody
  • EYA4_HUMAN antibody
  • Eyes absent 4 antibody
  • Eyes absent homolog 4 (Drosophila) antibody
  • Eyes absent homolog 4 antibody
  • HGNC:3522 antibody
  • OTTHUMP00000040267 antibody

  see all