概述

  • 产品名称Anti-EYA4抗体
    参阅全部 EYA4 一抗
  • 描述
    山羊多克隆抗体to EYA4
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide: DSQDLNEQSVKKTC, corresponding to N terminal amino acids 2-16 of Human EYA4 (UniProt ID: O95677).

  • 阳性对照
    • Human liver and testis tissues

性能

应用

Our Abpromise guarantee covers the use of ab110148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/128000.
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
  • 组织特异性Highly expressed in heart and skeletal muscle.
  • 疾病相关Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 序列相似性Belongs to the HAD-like hydrolase superfamily. EYA family.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CMD1J antibody
    • Deafness, autosomal dominant 10 antibody
    • DFNA 10 antibody
    • DFNA10 antibody
    • dJ78N10.1 (eyes absent (Drosophila) homolog 4) antibody
    • dJ78N10.1 (eyes absent) antibody
    • EYA 4 antibody
    • eya4 antibody
    • EYA4_HUMAN antibody
    • Eyes absent 4 antibody
    • Eyes absent homolog 4 (Drosophila) antibody
    • Eyes absent homolog 4 antibody
    • HGNC:3522 antibody
    • OTTHUMP00000040267 antibody
    see all

Anti-EYA4 antibody 图像

  • ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human liver by Immunohistochemistry.
  • ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human testis by Immunohistochemistry.

Anti-EYA4 antibody (ab110148)参考文献

ab110148 has not yet been referenced specifically in any publications.

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