概述

  • 产品名称Anti-EYA3抗体
    参阅全部 EYA3 一抗
  • 描述
    兔多克隆抗体to EYA3
  • 经测试应用适用于: ICC/IF, IHC-P, IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to Human EYA3 aa 30-60.
    Database link: Q99504

  • 阳性对照
    • HeLa whole cell lysate. IHC controls: Breast Carcinoma, Colon Carcinoma

性能

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应用

Our Abpromise guarantee covers the use of ab95877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/250 - 1/2000.
IHC-P 1/500 - 1/2000.
IP Use at 2-5 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
    • 序列相似性Belongs to the HAD-like hydrolase superfamily. EYA family.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR. Ser-266 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX.
    • 细胞定位Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AI844637 antibody
      • DKFZp686C132 antibody
      • EYA3 antibody
      • EYA3_HUMAN antibody
      • Eyes absent 3 antibody
      • Eyes absent 3 homolog (Drosophila) antibody
      • Eyes absent homolog 3 antibody
      • OTTMUSP00000010370 antibody
      • RP11-460I13.4 antibody
      • RP23-442A20.1 antibody
      see all

    Anti-EYA3 antibody (ab95877)参考文献

    ab95877 has not yet been referenced specifically in any publications.

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