概述

  • 产品名称Anti-EYA2抗体
    参阅全部 EYA2 一抗
  • 描述
    兔多克隆抗体to EYA2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Rabbit, Horse, Cow, Cat, Human, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 200-249 (EAPHNVSQSS ESLAGDYNTH NGPSTPAKEG DTDRPHRASD GKLRGRSKRS) of Rat EYA2 (NP_569111).

  • 阳性对照
    • Rat muscle lysate.

性能

应用

Our Abpromise guarantee covers the use of ab116075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
  • 组织特异性Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
  • 序列相似性Belongs to the HAD-like hydrolase superfamily. EYA family.
  • 发展阶段At the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EAB 1 antibody
    • EAB1 antibody
    • EYA 2 antibody
    • EYA2 antibody
    • EYA2_HUMAN antibody
    • eyes absent 2 homolog (Drosophila) antibody
    • Eyes absent homolog 2 (Drosophila) antibody
    • Eyes absent homolog 2 antibody
    • Translation of this uORF probably lowers the translation efficiency of EYA2 antibody
    see all

Anti-EYA2 antibody 图像

  • Anti-EYA2 antibody (ab116075) at 1 µg/ml + Rat muscle lysate at 10 µg

    Predicted band size : 58 kDa

Anti-EYA2 antibody (ab116075)参考文献

ab116075 has not yet been referenced specifically in any publications.

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