Anti-Extracellular matrix protein 1抗体[SPM217] (ab17921)

概述

  • 产品名称Anti-Extracellular matrix protein 1抗体[SPM217]
    参阅全部 Extracellular matrix protein 1 一抗
  • 描述
    小鼠单克隆抗体[SPM217] to Extracellular matrix protein 1
  • 特异性ab17921 reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.
  • 经测试应用适用于: ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat
  • 免疫原

    Full length native protein (purified) corresponding to Human Secretory Component Glycoprotein. Secretory Component protein isolated from human colostrum.

  • 表位Not determined
  • 阳性对照
    • Stomach, Lung, or breast tumor.

性能

应用

Our Abpromise guarantee covers the use of ab17921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 1 - 2 µg/ml.
IHC-P 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.

靶标

  • 功能Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
  • 组织特异性Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
  • 疾病相关Defects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ECM 1 antibody
    • Ecm1 antibody
    • ECM1_HUMAN antibody
    • Extracellular matrix protein 1 antibody
    • Secretory component p85 antibody
    • URBWD antibody
    see all

Anti-Extracellular matrix protein 1 antibody [SPM217] 图像

  • Human colon carcinoma stained with ab17921.

Anti-Extracellular matrix protein 1 antibody [SPM217] (ab17921)参考文献

ab17921 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab17921.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"