概述

  • 产品名称Anti-Ext2抗体
    参阅全部 Ext2 一抗
  • 描述
    小鼠单克隆抗体to Ext2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment: GFSTWTYRQG YDVSIPVYSP LSAEVDLPEK GPGPRQYFLL SSQVGLHPEY REDLEALQVK HGESVLVLDK CTNLSEGVLS VRKRCHKHQV FDYPQVLQEA , corresponding to amino acids 216-315 of Human Ext2

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG1
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab54711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.
    • 组织特异性Ubiquitous.
    • 通路Protein modification; protein glycosylation.
    • 疾病相关Defects in EXT2 are a cause of hereditary multiple exostoses type 2 (EXT2) [MIM:133701]. EXT is a genetically heterogeneous bone disorder caused by genes segregating on human chromosomes 8, 11, and 19 and designated EXT1, EXT2 and EXT3 respectively. EXT is a dominantly inherited skeletal disorder primarily affecting endochondral bone during growth. The disease is characterized by formation of numerous cartilage-capped, benign bone tumors (osteocartilaginous exostoses or osteochondromas) that are often accompanied by skeletal deformities and short stature. In a small percentage of cases exostoses have exhibited malignant transformation resulting in an osteosarcoma or chondrosarcoma. Osteochondromas development can also occur as a sporadic event.
      Defects in EXT2 are the cause of Potocki-Shaffer syndrome (PSS) [MIM:601224]. It is a contiguous gene syndrome due to proximal deletion of chromosome 11p11.2, including EXT2 and ALX4.
    • 序列相似性Belongs to the glycosyltransferase 47 family.
    • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus membrane. The EXT1/EXT2 complex is localized in the Golgi apparatus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Exostoses (multiple) 2 antibody
      • Exostosin 2 antibody
      • Exostosin-2 antibody
      • EXT2 antibody
      • EXT2_HUMAN antibody
      • Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase antibody
      • Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody
      • Multiple exostoses protein 2 antibody
      • N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase antibody
      • Putative tumor suppressor protein EXT2 antibody
      • SOTV antibody
      see all

    Anti-Ext2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab54711 Ext2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Anti-Ext2 antibody (ab54711)参考文献

    ab54711 has not yet been referenced specifically in any publications.

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