概述

  • 产品名称Anti-EXOSC7抗体
    参阅全部 EXOSC7 一抗
  • 描述
    小鼠多克隆抗体to EXOSC7
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1 - 291 of Human EXOSC7 (NP_055819.1)

  • 阳性对照
    • WB: Jurkat cell lysate; ICC/IF: HeLa cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab89104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 32 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
  • 序列相似性Belongs to the RNase PH family.
  • 细胞定位Nucleus > nucleolus. Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EAP1 antibody
    • EXOS7_HUMAN antibody
    • Exosc7 antibody
    • Exosome complex component RRP42 antibody
    • Exosome complex exonuclease RRP42 antibody
    • Exosome component 7 antibody
    • FLJ26543 antibody
    • hRrp42p antibody
    • KIAA0116 antibody
    • p8 antibody
    • Ribosomal RNA processing protein 42 antibody
    • Ribosomal RNA-processing protein 42 antibody
    • RRP42 antibody
    • Rrp42p antibody
    see all

Anti-EXOSC7 antibody 图像

  • Anti-EXOSC7 antibody (ab89104) at 1 µg/ml + Jurkat cell lysate at 50 µg

    Predicted band size : 32 kDa
  • All lanes : Anti-EXOSC7 antibody (ab89104) at 1 µg/ml

    Lane 1 : EXOSC7-transfected 293T cell lysate
    Lane 2 : non transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 32 kDa
    Observed band size : 32 kDa
  • Analysis of EXOSC7 expression in PFA-fixed, permeabilized HeLa cells using ab89104 at 10 µg/ml, followed by a fluorescein-conjugated secondary antibody.

Anti-EXOSC7 antibody (ab89104)参考文献

ab89104 has not yet been referenced specifically in any publications.

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