概述

  • 产品名称Anti-EVC2抗体
    参阅全部 EVC2 一抗
  • 描述
    山羊多克隆抗体to EVC2
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    C-LNAKKAMRALGMD

    , corresponding to C terminal amino acids 1296-1308 of Human EVC2.

  • 阳性对照
    • Human placenta and testis tissues

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab113924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/16000.
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 相关性EVC2 is an integral membrane protein that plays a vital role in bone formation and skeletal development. Defects in EVC2 are a cause of Ellis-van Creveld syndrome (EVC), also known as chondroectodermal dysplasia. EVC is an autosomal recessive disorder characterized by the clinical tetrad of chondrodystrophy, polydactyly, ectodermal dysplasia and cardiac anomalies. Patients manifest short-limb dwarfism, short ribs, postaxial polydactyly and dysplastic nails and teeth. Congenital heart defects, most commonly an atrioventricular septal defect, are observed in 60% of affected individuals. Defects in Defects in EVC2 are also a cause of acrofacial dysostosis Weyers type (WAD), also known as Curry-Hall syndrome. Acrofacial dysostoses are a heterogeneous group of disorders combining limb defects with facial abnormalities. WAD is an autosomal dominant disorder characterized by dysplastic nails, postaxial polydactyly, acrofacial dysostosis, short limbs and short stature. The phenotype is milder than Ellis-van Creveld syndrome.
  • 细胞定位Membrane; Multi-pass membrane protein
  • 数据库链接
  • 别名
    • Ellis van Creveld syndrome 2 antibody
    • LBN antibody
    • Limbin antibody

Anti-EVC2 antibody 图像

  • ab113924, at 3.75 µg/ml, staining EVC2 in formalin fixed, paraffin embedded Human placenta tissue by Immunohistochemistry.
  • ab113924, at 3.75 µg/ml, staining EVC2 in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.

Anti-EVC2 antibody (ab113924)参考文献

ab113924 has not yet been referenced specifically in any publications.

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