Anti-ETS1 associated protein II抗体[16] (ab67458)

概述

  • 产品名称Anti-ETS1 associated protein II抗体[16]
    参阅全部 ETS1 associated protein II 一抗
  • 描述
    小鼠单克隆抗体[16] to ETS1 associated protein II
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant ETS1 associated protein II (Human) expressed in E. coli expression system.

  • 阳性对照
    • Human recombinant ETS1 associated protein II.

性能

应用

Our Abpromise guarantee covers the use of ab67458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 41 kDa).
ELISA Use at an assay dependent dilution.

靶标

  • 功能DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the CCR4/nocturin family.
  • 细胞定位Nucleus. Nucleus > PML body.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5'-Tyr-DNA phosphodiesterase antibody
    • 5'-tyrosyl-DNA phosphodiesterase antibody
    • AD 022 antibody
    • AD022 antibody
    • dJ30M3.3 antibody
    • EAP 2 antibody
    • EAP II antibody
    • EAP2 antibody
    • EAPII antibody
    • ETS 1 associated protein 2 antibody
    • ETS 1 associated protein II antibody
    • ETS1 associated protein 2 antibody
    • ETS1-associated protein 2 antibody
    • ETS1-associated protein II antibody
    • MGC111021 antibody
    • MGC9099 antibody
    • RP1-30M3.3 antibody
    • tdp2 antibody
    • TRAF and TNF receptor associated protein antibody
    • TRAF and TNF receptor-associated protein antibody
    • TTRAP antibody
    • TYDP2_HUMAN antibody
    • Tyr DNA phosphodiesterase 2 antibody
    • Tyr-DNA phosphodiesterase 2 antibody
    • Tyrosyl DNA phosphodiesterase 2 antibody
    • Tyrosyl-DNA phosphodiesterase 2 antibody
    see all

Anti-ETS1 associated protein II antibody [16] 图像

  • Anti-ETS1 associated protein II antibody [16] (ab67458) at 1/1000 dilution + human recombinant ETS1 associated protein II.

    Predicted band size : 41 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)

Anti-ETS1 associated protein II antibody [16] (ab67458)参考文献

ab67458 has not yet been referenced specifically in any publications.

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