概述

  • 产品名称Anti-ETHE1抗体
    参阅全部 ETHE1 一抗
  • 描述
    兔多克隆抗体to ETHE1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 92-141 (RSLLPGCQSV ISRLSGAQAD LHIEDGDSIR FGRFALETRA SPGHTPGCVT) of Human ETHE1 (NP_055112).

  • 阳性对照
    • COLO205 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab108138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Probably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53-induced apoptosis by preventing nuclear localization of RELA.
  • 组织特异性Ubiquitously expressed.
  • 疾病相关Defects in ETHE1 are a cause of ethylmalonic encephalopathy (EE) [MIM:602473]. EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, diarrhea, leading to death in the first decade of life. It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria.
  • 序列相似性Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • 细胞定位Cytoplasm. Nucleus. Mitochondrion matrix. According to PubMed:12398897, it is cytoplasmic and nuclear. According to PubMed:14732903, it is found in the mitochondrial matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ethe1 antibody
    • ETHE1 protein, mitochondrial precursor antibody
    • ETHE1_HUMAN antibody
    • ethylmalonic encephalopathy 1 antibody
    • Ethylmalonic encephalopathy protein 1 antibody
    • hepatoma subtracted clone one antibody
    • Hepatoma subtracted clone one protein antibody
    • HSCO antibody
    • mitochondrial antibody
    • Protein ETHE1 antibody
    • Protein ETHE1 mitochondrial antibody
    • YF13H12 antibody
    see all

Anti-ETHE1 antibody 图像

  • Anti-ETHE1 antibody (ab108138) at 1 µg/ml + COLO205 cell lysate at 10 µg

    Predicted band size : 28 kDa

Anti-ETHE1 antibody (ab108138)参考文献

ab108138 has not yet been referenced specifically in any publications.

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