Anti-Estrogen Related Receptor gamma抗体(ab82319)

概述

  • 产品名称
    Anti-Estrogen Related Receptor gamma抗体
    参阅全部 Estrogen Related Receptor gamma 一抗
  • 描述
    兔多克隆抗体to Estrogen Related Receptor gamma
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH and selected from the center region of Human Estrogen Related Receptor gamma.

  • 阳性对照
    • 293 cell line lysate; mouse spleen tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab82319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Detects a band of approximately 55 kDa (predicted molecular weight: 51 kDa).
ELISA 1/1000.

靶标

  • 功能
    Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.
  • 组织特异性
    Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
  • 序列相似性
    Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 发展阶段
    Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.
  • 翻译后修饰
    Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
    Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp781L1617 antibody
    • ERR 3 antibody
    • ERR G2 antibody
    • ERR gamma 2 antibody
    • ERR gamma-2 antibody
    • ERR3 antibody
    • ERR3_HUMAN antibody
    • ERRG 2 antibody
    • ERRG2 antibody
    • ERRgamma antibody
    • ESRRG antibody
    • Estrogen receptor related protein 3 antibody
    • Estrogen receptor-related protein 3 antibody
    • Estrogen-related receptor gamma antibody
    • FLJ16023 antibody
    • KIAA0832 antibody
    • NR3B3 antibody
    • Nuclear receptor subfamily 3 group B member 3 antibody
    see all

Anti-Estrogen Related Receptor gamma antibody 图像

  • Anti-Estrogen Related Receptor gamma antibody (ab82319) at 1/50 dilution (purified) + mouse spleen lysate at 35 µg

    Predicted band size : 51 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 14.5 kDa,25 kDa. We are unsure as to the identity of these extra bands.
  • Anti-Estrogen Related Receptor gamma antibody (ab82319) at 1/50 dilution (purified) + 293 cell lysate at 35 µg

    Predicted band size : 51 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)

实验方案

Anti-Estrogen Related Receptor gamma antibody (ab82319)参考文献

This product has been referenced in:
  • Luo Y  et al. Estrogen-related receptor ? serves a role in blood pressure homeostasis during pregnancy. Mol Endocrinol 28:965-75 (2014). Read more (PubMed: 24725083) »
  • Heckler MM  et al. ERK/MAPK regulates ERR? expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer. FEBS J 281:2431-42 (2014). Read more (PubMed: 24684682) »

See all 5 Publications for this product

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