Anti-Estrogen Receptor alpha (phospho S104 + S106)抗体[EPR1827] (ab75753)


  • 产品名称Anti-Estrogen Receptor alpha (phospho S104 + S106)抗体[EPR1827]
    参阅全部 Estrogen Receptor alpha 一抗
  • 描述
    兔单克隆抗体[EPR1827] to Estrogen Receptor alpha (phospho S104 + S106)
  • 特异性ab75753 only detects Estrogen Receptor alpha phosphorylated on Serine 104/106.
  • 经测试应用适用于: WB, ICC/IFmore details
    不适用于: Flow Cyt,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A phospho-specific peptide corresponding to residues surrounding Serine 104/106 of human Estrogen Receptor alpha.

  • 阳性对照
    • MCF-7 cell lysates. MCF-7 cells.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    A trial size is available to purchase for this antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.




Our Abpromise guarantee covers the use of ab75753 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Detects a band of approximately 66 kDa (predicted molecular weight: 66 kDa).
ICC/IF 1/100 - 1/250.
  • 应用说明Is unsuitable for Flow Cyt,IHC-P or IP.
  • 靶标

    • 功能Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
    • 序列相似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
    • 翻译后修饰Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
      Glycosylated; contains N-acetylglucosamine, probably O-linked.
      Ubiquitinated. Deubiquitinated by OTUB1.
      Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
      Palmitoylated (isoform 3). Not biotinylated (isoform 3).
    • 细胞定位Nucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation.
    • Information by UniProt
    • 数据库链接
    • 别名
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    Anti-Estrogen Receptor alpha (phospho S104 + S106) antibody [EPR1827] (ab75753)参考文献

    This product has been referenced in:
    • Held JM  et al. Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305. Mol Cancer Res 10:1120-32 (2012). Read more (PubMed: 22669764) »

    See 1 Publication for this product

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