Estrogen Receptor alpha肽(ab4906)

概述

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab4906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the monoclonal antibody that reacts with this product and estrogen receptor a, catalog ab2746. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • DKFZp686N23123
    • ER
    • ER alpha
    • ER-alpha
    • Era
    • ESR
    • ESR1
    • ESR1_HUMAN
    • ESRA
    • Estradiol receptor
    • Estrogen nuclear receptor alpha
    • Estrogen receptor
    • Estrogen receptor 1
    • Estrogen receptor alpha
    • Estrogen receptor alpha 3*,4,5,6,7*/822 isoform
    • Estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
    • Estrogen receptor alpha delta 3*,4,5,6,7*/819 2 isoform
    • Estrogen receptor alpha delta 4 +49 isoform
    • Estrogen receptor alpha delta 4*,5,6,7*/654 isoform
    • Estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
    • Estrogen receptor alpha E1 E2 1 2
    • Estrogen receptor alpha E1 N2 E2 1 2
    • ESTRR
    • NR3A1
    • Nuclear receptor subfamily 3 group A member 1
    see all
  • 功能Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 翻译后修饰Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
    Glycosylated; contains N-acetylglucosamine, probably O-linked.
    Ubiquitinated. Deubiquitinated by OTUB1.
    Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
    Palmitoylated (isoform 3). Not biotinylated (isoform 3).
  • 细胞定位Nucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation.
  • Information by UniProt

Estrogen Receptor alpha peptide (ab4906)参考文献

ab4906 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. This is a 15 amino acid (amino acids 247-261) synthetic peptide whose sequence is from the ER-DNA binding domain of the estrogen receptor alpha. The sequence of this peptide is (amino to carboxy terminus): E(247)VGMMKGGIRKDR...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"