概述

  • 产品名称Anti-ESRP2抗体
    参阅全部 ESRP2 一抗
  • 描述
    兔多克隆抗体to ESRP2
  • 特异性ab113486 is predicted to not cross-react with other ESRP family members. At least three isoforms of ESRP2 are known to exist; ab113486 will detect all three.
  • 经测试应用适用于: ICC/IF, WB, ICC, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide containing a 17 residue sequence from the C terminal region of Human ESRP2 (GenBank accession no. NP_079215).

  • 阳性对照
    • Human lung tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab113486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 78 kDa.
ICC Use a concentration of 5 µg/ml.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
  • 组织特异性Epithelial cell-specific.
  • 序列相似性Belongs to the ESRP family.
    Contains 3 RRM (RNA recognition motif) domains.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Epithelial splicing regulatory protein 2 antibody
    • ESRP 2 antibody
    • ESRP2 antibody
    • ESRP2_HUMAN antibody
    • FLJ21918 antibody
    • FLJ22248 antibody
    • RBM35B antibody
    • RNA binding motif protein 35A antibody
    • RNA binding motif protein 35B antibody
    • RNA binding protein 35B antibody
    • RNA-binding motif protein 35B antibody
    • RNA-binding protein 35B antibody
    see all

Anti-ESRP2 antibody 图像

  • Immunofluorescence of ESRP2 in Human lung tissue cells with ab113486 at 20 ug/mL.
  • Anti-ESRP2 antibody (ab113486) at 1 µg/ml + Human lung tissue lysate at 15 µg

    Predicted band size : 78 kDa
  • Immunohistochemical analysis of Human lung tissue, staining ESRP2 with ab113486 at 5 µg/ml.

Anti-ESRP2 antibody (ab113486)参考文献

This product has been referenced in:
  • Ishii H  et al. Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms. J Biol Chem 289:27386-99 (2014). Read more (PubMed: 25143390) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab113486.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"