Anti-ESE1抗体[ELF3B10C4] (ab50746)

概述

  • 产品名称
    Anti-ESE1抗体[ELF3B10C4]
    参阅全部 ESE1 一抗
  • 描述
    小鼠单克隆抗体[ELF3B10C4] to ESE1
  • 经测试应用
    适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Recombinant fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment (Human)

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    Protein G purified from culture of supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (~95%) fetal bovine serum. Filtered through a 0.22µm membrane
  • 克隆
    单克隆
  • 克隆编号
    ELF3B10C4
  • 同种型
    IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab50746 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 41 kDa.
Dot blot Use at an assay dependent dilution.

靶标

  • 功能
    Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
  • 组织特异性
    Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
  • 序列相似性
    Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • 结构域
    the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • 细胞定位
    Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E74 like factor 3 antibody
    • E74 like factor 3 ets domain transcription factor antibody
    • E74 like factor 3 ets domain transcription factor epithelial specific antibody
    • E74 like factor 3 ETS domain transcription factor serine box epithelial specific antibody
    • E74-like factor 3 antibody
    • Elf3 antibody
    • ELF3_HUMAN antibody
    • Epithelial restricted with serine box antibody
    • Epithelial-restricted with serine box antibody
    • Epithelium restricted Ets protein ESX antibody
    • Epithelium specific Ets factor 1 antibody
    • Epithelium specific Ets transcription factor 1 antibody
    • Epithelium-restricted Ets protein ESX antibody
    • Epithelium-specific Ets transcription factor 1 antibody
    • EPR 1 antibody
    • EPR1 antibody
    • ERT antibody
    • ESE-1 antibody
    • ESX antibody
    • Ets domain transcription factor serine box antibody
    • Ets domain transcription factor serine box epithelial specific antibody
    • Ets transcription factor antibody
    • ETS-related transcription factor Elf-3 antibody
    • jen antibody
    • MGC139318 antibody
    see all

图片

  • Lane 1 : Molecular weight markers
    Lane 2 : Anti-ESE1 antibody [ELF3B10C4] (ab50746)

    Lane 1 : As above
    Lane 2 : Immunising peptide


    Predicted band size : 41 kDa
    Observed band size : 57 kDa (why is the actual band size different from the predicted?)

实验方案

文献

ab50746 has not yet been referenced specifically in any publications.

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