Anti-ESCO2抗体(ab107277)

概述

• 产品名称
  Anti-ESCO2抗体
  参阅全部 ESCO2 一抗
• 描述
  兔多克隆抗体to ESCO2
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Mouse, Human
  
• 免疫原

  KLH conjugated synthetic peptide corresponding to a region within internal sequence amino acids 135-165 of Human ESCO2 (NP_001017420.1).

• 阳性对照
  • Mouse stomach tissue lysate

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
• 存储溶液
  Preservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 纯化说明
  ab107277 is purified through a protein A column, followed by peptide affinity purification.
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Cell Biology
  • Cell Cycle
  • Cell Division
  • Chromatid Cohesion

  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Chromosome Structure
  • Chromatid Cohesion

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 相关性
  ESCO2 is an acetyltransferase required for the establishment of sister chromatid cohesion, and couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Defects in ESCO2 are the cause of Roberts syndrome (RBS), a rare autosomal recessive disorder characterized by pre- and postnatal growth retardation, microcephaly, bilateral cleft lip and palate, and mesomelic symmetric limb reduction. Severely affected infants may be stillborn or die shortly after birth. RBS chromosomes have a lack of cohesion involving the heterochromatic C-banding regions around centromeres and the distal portion of the long arm of the Y chromosome (known as premature centromere separation, heterochromatin repulsion or puffing, or RS effect). Defects in ESCO2 are also the cause of SC phocomelia syndrome, also known as SC pseudothalidomide syndrome. SC phocomelia syndrome has a milder phenotype than RBS, with a lesser degree of symmetric limb reduction and additionally includes flexion contractures of various joints, midfacial hemangioma, hypoplastic cartilage of ears and nose, scant silvery-blond hair, and cloudy corneae. Although microcephaly is present, mental retardation may be mild and survival into adulthood is common.
• 细胞定位
  Nuclear
• 数据库链接
  • Entrez Gene: 157570 Human
  • Omim: 609353 Human
• 别名
  • CTF7, S. CEREVISIAE, HOMOLOG OF, 2 antibody
  • ECO1 homolog 2 antibody
  • ECO1, S. CEREVISIAE, HOMOLOG OF, 2 antibody

  • EFO2 antibody
  • ESO1, S. POMBE, HOMOLOG OF, 2 antibody
  • ESTABLISHMENT FACTOR ORTHOLOG 2; EFO2 antibody
  • Establishment of cohesion 1 homolog 2 antibody
  • Establishment of cohesion 1 homolog 2 (S. cerevisiae) antibody
  • N acetyltransferase ESCO2 antibody
  • RBS antibody
  • Roberts syndrome antibody

  see all

实验方案

• Western blot protocols