概述

  • 产品名称Anti-ERV31抗体
    参阅全部 ERV31 一抗
  • 描述
    兔多克隆抗体to ERV31
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 444-474 of Human ERV31 (NP_001007254.2).

  • 阳性对照
    • 293 and HepG2 cell line lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab116723 is purified through a Protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab116723 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 68 kDa.

靶标

  • 功能Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro.
    SU mediates receptor recognition.
    TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.
  • 组织特异性Expressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level in bone marrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis, thymus, thyroid, trachea.
  • 序列相似性Belongs to the gamma type-C retroviral envelope protein family. HERV class-I R env subfamily.
  • 发展阶段Highly expressed in primitive adrenal cortex and placenta. Expressed at lower level in developing nervous tissues, tongue, heart, gut, kidney, columna vertebralis and liver.
  • 结构域Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.
  • 翻译后修饰Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity). Has been mainly detected in vivo as an 65 kDa unprocessed polyprotein precursor.
    The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
  • 细胞定位Virion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Endogenous retroviral sequence 3 antibody
    • Endogenous retrovirus group 3 member 1 antibody
    • ENR1_HUMAN antibody
    • Envelope polyprotein antibody
    • envR antibody
    • ERV R antibody
    • ERV-3 envelope protein antibody
    • ERV-R envelope protein antibody
    • ERV3 1 envelope protein antibody
    • ERV3 antibody
    • ERV3 envelope protein antibody
    • ERV3-1 antibody
    • ERVR antibody
    • FLJ23884 antibody
    • HERV R antibody
    • HERV-R envelope protein antibody
    • HERV-R_7q21.2 provirus ancestral Env polyprotein antibody
    • HERVR antibody
    • SU antibody
    • TM antibody
    • Transmembrane protein antibody
    see all

Anti-ERV31 antibody 图像

  • All lanes : Anti-ERV31 antibody (ab116723) at 1/100 dilution

    Lane 1 : 293 cell line lysate
    Lane 2 : HepG2 cell line lysate

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 68 kDa

Anti-ERV31 antibody (ab116723)参考文献

This product has been referenced in:

See all 2 Publications for this product

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