概述

  • 产品名称
  • 描述
    兔多克隆抗体to ERRFI1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Synthetic peptide:

    GISSATEKPDSKTKMD

    conjugated to KLH by an N-terminal Cysteine residue linker, corresponding to amino acids 431-446 of Rat ERRFI1

性能

应用

Our Abpromise guarantee covers the use of ab50272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.2 - 0.4 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 51 kDa).

靶标

  • 功能
    Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.
  • 序列相似性
    Belongs to the MIG6 family.
  • 结构域
    The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer.
  • 细胞定位
    Cytoplasm. Cell membrane. Nucleus. Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ERBB receptor feedback inhibitor 1 antibody
    • ERRFI_HUMAN antibody
    • Errfi1 antibody
    • GENE 33 antibody
    • Gene 33, rat, homolog of antibody
    • Mig-6 antibody
    • MIG6 antibody
    • mitogen inducible gene 6 antibody
    • mitogen inducible gene 6 protein antibody
    • Mitogen-inducible gene 6 protein antibody
    • RALT antibody
    • receptor-associated late transducer antibody
    see all

实验方案

文献

ab50272 has not yet been referenced specifically in any publications.

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