概述

  • 产品名称Anti-ERK5抗体
    参阅全部 ERK5 一抗
  • 描述
    兔多克隆抗体to ERK5
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Dog, Chimpanzee, Gorilla, Opossum, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region between residue 475 and 525 of Human ERK5 (NP_002740.2).

  • 阳性对照
    • HeLa whole cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab95078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.
    • 组织特异性Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.
    • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
      Contains 1 protein kinase domain.
    • 结构域The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell.
      The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    • 翻译后修饰Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
    • 细胞定位Cytoplasm. Nucleus. Translocates to the nucleus upon activation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Big MAP kinase 1 antibody
      • BMK 1 antibody
      • BMK 1 kinase antibody
      • BMK-1 antibody
      • BMK1 antibody
      • BMK1 Kinase antibody
      • EC 2.7.11.24 antibody
      • ERK 4 antibody
      • ERK 5 antibody
      • ERK-5 antibody
      • ERK4 antibody
      • ERK5 antibody
      • Extracellular signal regulated kinase 5 antibody
      • Extracellular signal-regulated kinase 5 antibody
      • MAP kinase 7 antibody
      • MAPK 7 antibody
      • MAPK7 antibody
      • Mitogen activated protein kinase 7 antibody
      • Mitogen-activated protein kinase 7 antibody
      • MK07_HUMAN antibody
      • OTTHUMP00000065906 antibody
      • OTTHUMP00000065907 antibody
      • PRKM 7 antibody
      • PRKM7 antibody
      • PROTEIN KINASE, MITOGEN-ACTIVATED, 7 antibody
      see all

    Anti-ERK5 antibody 图像

    • Detection of ERK5 by Western Blot of Immunprecipitate.
      anti-ERK5 at 1µg/ml staining ERK5 in HeLa whole cell lysate immunoprecipitated using ab95078 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 3 seconds.

    Anti-ERK5 antibody (ab95078)参考文献

    ab95078 has not yet been referenced specifically in any publications.

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