Anti-ERK2抗体, prediluted (ab15283)


  • 产品名称Anti-ERK2抗体, prediluted
    参阅全部 ERK2 一抗
  • 描述
    兔多克隆抗体to ERK2, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Mouse) (C terminal).

  • 阳性对照
    • A431 cells, Breast carcinoma



Our Abpromise guarantee covers the use of ab15283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IHC-P: 1/1. Perform enzymatic antigen retrieval before commencing with IHC staining protocol, by boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.
      Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
    • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
      Contains 1 protein kinase domain.
    • 结构域The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    • 翻译后修饰Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-187.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ERK 2 antibody
      • ERK antibody
      • ERK-2 antibody
      • ERT1 antibody
      • Extracellular Signal Regulated Kinase 2 antibody
      • Extracellular signal-regulated kinase 2 antibody
      • MAP kinase 1 antibody
      • MAP kinase 2 antibody
      • MAP kinase isoform p42 antibody
      • MAPK 1 antibody
      • MAPK 2 antibody
      • Mapk1 antibody
      • MAPK2 antibody
      • Mitogen-activated protein kinase 1 antibody
      • Mitogen-activated protein kinase 2 antibody
      • MK01_HUMAN antibody
      • P38 antibody
      • P40 antibody
      • P41 antibody
      • p42-MAPK antibody
      • P42MAPK antibody
      • PRKM1 antibody
      • PRKM2 antibody
      • protein kinase, mitogen-activated, 1 antibody
      • protein kinase, mitogen-activated, 2 antibody
      • protein tyrosine kinase ERK2 antibody
      see all

    Anti-ERK2 antibody, prediluted 图像

    • ab15283 staining ERK2 in breast carcinoma by IHC-P.

    Anti-ERK2 antibody, prediluted (ab15283)参考文献

    ab15283 has not yet been referenced specifically in any publications.

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