概述

  • 产品名称ERK1 + ERK2肽

描述

  • 性质Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab108469 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-ERK1 + ERK2 antibody - Loading Control (ab94484)

  • 纯度70 - 90% by HPLC.

  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • ERK 1
    • ERK 2
    • ERK-2
    • ERK1
    • erk1/2
    • ERK2
    • ERT1
    • ERT2
    • Extracellular signal regulated kinase 1
    • Extracellular signal-regulated kinase 2
    • MAP kinase 1
    • MAP kinase 2
    • MAP kinase isoform p42
    • MAP kinase isoform p44
    • MAPK 1
    • MAPK 2
    • MAPK 3
    • Mapk1
    • MAPK2
    • MAPK3
    • Mitogen-activated protein kinase 1
    • Mitogen-activated protein kinase 2
    • MK01_HUMAN
    • p38
    • p40
    • p41
    • p42-MAPK
    • PRKM 2
    see all
  • 功能Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.
    Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • 结构域The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻译后修饰Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-187.
  • 细胞定位Nucleus.
  • Information by UniProt

ERK1 + ERK2 peptide (ab108469)参考文献

ab108469 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab108469.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"