概述

  • 产品名称Anti-ERCC8抗体
    参阅全部 ERCC8 一抗
  • 描述
    兔多克隆抗体to ERCC8
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    KLH conjugated synthetic peptide between internal sequence amino acids 210-238 of Human ERCC8 (NP_000073.1).

  • 阳性对照
    • Mouse spleen tissue lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab107290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 44 kDa.

靶标

  • 功能Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
  • 通路Protein modification; protein ubiquitination.
  • 疾病相关Defects in ERCC8 are the cause of Cockayne syndrome type A (CSA) [MIM:216400]. Cockayne syndrome is a rare disorder characterized by cutaneous sensitivity to sunlight, abnormal and slow growth, cachectic dwarfism, progeroid appearance, progressive pigmentary retinopathy and sensorineural deafness. There is delayed neural development and severe progressive neurologic degeneration resulting in mental retardation. Two clinical forms are recognized: in the classical form or Cockayne syndrome type 1, the symptoms are progressive and typically become apparent within the first few years or life; the less common Cockayne syndrome type 2 is characterized by more severe symptoms that manifest prenatally. Cockayne syndrome shows some overlap with certain forms of xeroderma pigmentosum. Unlike xeroderma pigmentosum, patients with Cockayne syndrome do not manifest increased freckling and other pigmentation abnormalities in the skin and have no significant increase in skin cancer.
  • 序列相似性Contains 5 WD repeats.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CKN1 antibody
    • Cockayne syndrome type A antibody
    • Cockayne syndrome WD repeat protein CSA antibody
    • CSA antibody
    • DNA excision repair protein ERCC-8 antibody
    • DNA excision repair protein ERCC8 antibody
    • ERCC 8 antibody
    • ERCC8 antibody
    • ERCC8_HUMAN antibody
    • excision repair cross-complementing rodent repair deficiency, complementation group 8 antibody
    see all

Anti-ERCC8 antibody 图像

  • Anti-ERCC8 antibody (ab107290) at 1/100 dilution + Mouse spleen tissue lysate at 35 µg

    Predicted band size : 44 kDa

Anti-ERCC8 antibody (ab107290)参考文献

ab107290 has not yet been referenced specifically in any publications.

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