概述

  • 产品名称Anti-ERC1抗体
    参阅全部 ERC1 一抗
  • 描述
    兔多克隆抗体to ERC1
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between residues 700 and 750 of Human ERC1 (NP_829884.1).

  • 阳性对照
    • HeLa and 293T whole cell lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab95889 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/10000. Predicted molecular weight: 128 kDa.
IP Use at 2-5 µg/mg of lysate.

靶标

  • 功能Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
  • 组织特异性Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
  • 疾病相关Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving ERC1/RAB6IP2 is found in cause of thyroid papillary carcinomas. Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
  • 序列相似性Contains 1 FIP-RBD domain.
  • 细胞定位Cytoplasm. Membrane. Golgi apparatus membrane. In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cast 2 antibody
    • CAST2 antibody
    • CAZ associated structural protein 2 antibody
    • Elks antibody
    • ELKS/RAB6 interacting/CAST family member 1 antibody
    • ELKS/RAB6-interacting/CAST family member 1 antibody
    • ERC 1 antibody
    • ERC protein 1 antibody
    • ERC-1 antibody
    • Erc1 antibody
    • ERC1 protein antibody
    • KIAA1081 antibody
    • MGC12974 antibody
    • RAB6 interacting protein 2 antibody
    • RAB6-interacting protein 2 antibody
    • RAB6IP2 antibody
    • RB6I2_HUMAN antibody
    see all

Anti-ERC1 antibody 图像

  • All lanes : Anti-ERC1 antibody (ab95889) at 0.04 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg
    Lane 3 : HeLa whole cell lysate at 5 µg
    Lane 4 : 293T whole cell lysate at 50 µg


    Predicted band size : 128 kDa


    Exposure time : 10 seconds
  • Detection of ERC1 by Western Blot of Immunprecipitate.
    ab95889 at 1µg/ml staining ERC1 in HeLa whole cell lysate immunoprecipitated using ab95889 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
    Detection: Chemiluminescence with exposure time of 3 seconds.

Anti-ERC1 antibody (ab95889)参考文献

ab95889 has not yet been referenced specifically in any publications.

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