Anti-ErbB 3 (phospho Y1289)抗体(ab62435)

概述

  • 产品名称
    Anti-ErbB 3 (phospho Y1289)抗体
    参阅全部 ErbB 3 一抗
  • 描述
    兔多克隆抗体to ErbB 3 (phospho Y1289)
  • 特异性
    This antibody detects endogenous levels of HER3/ErbB3 only when phosphorylated at tyrosine 1289.
  • 经测试应用
    适用于: ICC/IF, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic phosphopeptide derived from human ErbB3 around the phosphorylation site of tyrosine 1289 (Q-G-YP-E-E).

  • 阳性对照
    • HeLa cells

性能

应用

Our Abpromise guarantee covers the use of ab62435 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/500 - 1/1000.
ELISA 1/10000.

靶标

  • 功能
    Binds and is activated by neuregulins and NTAK.
  • 组织特异性
    Epithelial tissues and brain.
  • 疾病相关
    Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
    Contains 1 protein kinase domain.
  • 发展阶段
    Overexpressed in a subset of human mammary tumors.
  • 结构域
    The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
  • 翻译后修饰
    Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
  • 细胞定位
    Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • c erbB 3 antibody
    • c erbB3 antibody
    • Erb b2 receptor tyrosine kinase 3 antibody
    • ErbB 3 antibody
    • ERBB3 antibody
    • ERBB3 protein antibody
    • erbB3 S antibody
    • ERBB3_HUMAN antibody
    • Glial growth factor receptor antibody
    • HER 3 antibody
    • HER3 antibody
    • Human epidermal growth factor receptor 3 antibody
    • LCCS2 antibody
    • MDA BF 1 antibody
    • MGC88033 antibody
    • p180 ErbB3 antibody
    • p45 sErbB3 antibody
    • p85 sErbB3 antibody
    • proto-oncogene-like protein c ErbB 3 antibody
    • proto-oncogene-like protein c ErbB3 antibody
    • Proto-oncogene-like protein c-ErbB-3 antibody
    • Receptor tyrosine protein kinase erbB 3 antibody
    • Receptor tyrosine protein kinase erbB3 antibody
    • Receptor tyrosine-protein kinase erbB-3 antibody
    • Tyrosine kinase type cell surface receptor HER3 antibody
    • Tyrosine kinase-type cell surface receptor HER3 antibody
    • v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody
    see all

图片

  • Immunofluorescent analysis of HeLa cells using ab62435 at a 1/500 dilution, in the presence (right) and absence (left) of immunising phosphopeptide.

文献

ab62435 has not yet been referenced specifically in any publications.

客户评价及客户问答

ab51044
-Note yet tested on frozen sections but has been tested on paraffin embedded sections
fixation methods: formalin
Recommended starting dilution: 1:50
Positive control: testis, brain
Negative control: protein is widely ex...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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