Customer reviews and FAQs

概述

  • 产品名称
    Anti-ErbB 3抗体[SGP1]
    参阅全部 ErbB 3 一抗
  • 描述
    小鼠单克隆抗体[SGP1] to ErbB 3
  • 经测试应用
    适用于: Flow Cyt, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chimpanzee
  • 免疫原

    Wheatgerm lectin purified cERBB3 protein from transfected human kidney fibroblasts

  • 表位
    Extracellular domain.

性能

应用

Our Abpromise guarantee covers the use of ab20162 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.

靶标

  • 功能
    Binds and is activated by neuregulins and NTAK.
  • 组织特异性
    Epithelial tissues and brain.
  • 疾病相关
    Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
    Contains 1 protein kinase domain.
  • 发展阶段
    Overexpressed in a subset of human mammary tumors.
  • 结构域
    The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
  • 翻译后修饰
    Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
  • 细胞定位
    Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
    see all
  • 别名
    • c erbB 3 antibody
    • c erbB3 antibody
    • Erb b2 receptor tyrosine kinase 3 antibody
    • ErbB 3 antibody
    • ERBB3 antibody
    • ERBB3 protein antibody
    • erbB3 S antibody
    • ERBB3_HUMAN antibody
    • Glial growth factor receptor antibody
    • HER 3 antibody
    • HER3 antibody
    • Human epidermal growth factor receptor 3 antibody
    • LCCS2 antibody
    • MDA BF 1 antibody
    • MGC88033 antibody
    • p180 ErbB3 antibody
    • p45 sErbB3 antibody
    • p85 sErbB3 antibody
    • proto-oncogene-like protein c ErbB 3 antibody
    • proto-oncogene-like protein c ErbB3 antibody
    • Proto-oncogene-like protein c-ErbB-3 antibody
    • Receptor tyrosine protein kinase erbB 3 antibody
    • Receptor tyrosine protein kinase erbB3 antibody
    • Receptor tyrosine-protein kinase erbB-3 antibody
    • Tyrosine kinase type cell surface receptor HER3 antibody
    • Tyrosine kinase-type cell surface receptor HER3 antibody
    • v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody
    see all

Anti-ErbB 3 antibody [SGP1] (ab20162)参考文献

This product has been referenced in:
  • Vollmann-Zwerenz A  et al. Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry--possibilities and limitations. Cytometry A 77:387-98 (2010). Read more (PubMed: 20151455) »
  • Srinivasan R  et al. Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. J Pathol 185:236-45 (1998). Read more (PubMed: 9771476) »

See all 3 Publications for this product

发表研究结果有使用 ab20162？请让我们知道，以便我们可以引用本数据表中的参考文章。

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2 Abreviews or Q&A

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Votes: Highest First

Inquiry: Dear Abcam Do you possibly have the protein sequence of this antibody? Thank you in advance for any help

Thank you for contacting us.

We unfortunately can not offer information other than already published on the datasheet. I am sorry I will not be more helpful with this antibody as we do not have the epitope information.

I hope this inf...

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At this moment I want to order an anti-HER3 antibody. In the past I used the SGP1 clone from your company (Anti-ErbB 3 antibody [SGP1] (ab20162)). I'm wondering what constituents the solution is composed of. From your site I understand that it is only ...

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Thank you for contacting us.

The buffer Ab20162 is composed of PBS with no additives such as sodium azide. We will always list the constituents of the buffer on our website when available.


I hope this information is helpf...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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