- 数据表
- 具体的参考文献 (3)
- 实验方案
概述
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产品名称Anti-ErbB 3抗体[SGP1]
参阅全部 ErbB 3 一抗 -
描述小鼠单克隆抗体[SGP1] to ErbB 3
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宿主Mouse
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经测试应用适用于: Flow Cyt, IPmore details
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种属反应性与反应: Human
预测可用于: Mouse, Rat, Chimpanzee
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免疫原
Wheatgerm lectin purified cERBB3 protein from transfected human kidney fibroblasts
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表位Extracellular domain.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: None
Constituents: PBS -
Concentration information loading... -
克隆单克隆
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克隆编号SGP1
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骨髓瘤NS0
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同种型IgG1
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轻链类型kappa
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab20162 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt | Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
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| IP | Use at an assay dependent concentration. |
靶标
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功能Binds and is activated by neuregulins and NTAK.
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组织特异性Epithelial tissues and brain.
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疾病相关Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
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序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Contains 1 protein kinase domain. -
发展阶段Overexpressed in a subset of human mammary tumors.
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结构域The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
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翻译后修饰Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
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细胞定位Secreted and Cell membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 451980 Chimpanzee
- Entrez Gene: 2065 Human
- Entrez Gene: 13867 Mouse
- Entrez Gene: 29496 Rat
- Omim: 190151 Human
- SwissProt: P21860 Human
- SwissProt: Q61526 Mouse
- SwissProt: Q62799 Rat
see all -
别名
- c erbB 3 antibody
- c erbB3 antibody
- Erb b2 receptor tyrosine kinase 3 antibody
see all
文献
This product has been referenced in:
- Vollmann-Zwerenz A et al. Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry--possibilities and limitations. Cytometry A 77:387-98 (2010). Read more (PubMed: 20151455) »
- Srinivasan R et al. Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. J Pathol 185:236-45 (1998). Read more (PubMed: 9771476) »
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"