概述
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产品名称Anti-ERAB抗体
参阅全部 ERAB 一抗 -
描述兔多克隆抗体to ERAB
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经测试应用适用于: WBmore details
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种属反应性与反应: Mouse, Human
预测可用于: Rat, Cow, Zebrafish
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免疫原
Synthetic peptide:
C-IRLDGAIRMQP
, corresponding to C terminal amino acids 251-261 of Human ERAB with a Cysteine residue linker -
阳性对照
- Jurkat, EC9706 and SGC cell lysates.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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存储溶液Preservative: 0.02% Sodium Azide
Constituents: PBS, pH 7.4 -
Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
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Positive Controls
应用
Our Abpromise guarantee covers the use of ab87535 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/500 - 1/3000. Detects a band of approximately 27 kDa (predicted molecular weight: 27 kDa). |
靶标
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功能Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
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组织特异性Expressed in normal tissues but is overexpressed in neurons affected in AD.
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疾病相关Defects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) [MIM:300438]. MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills.
Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10) [MIM:300220]. MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior.
A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. -
序列相似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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细胞定位Mitochondrion.
- Information by UniProt
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数据库链接
- Entrez Gene: 281809 Cow
- Entrez Gene: 3028 Human
- Entrez Gene: 15108 Mouse
- Entrez Gene: 63864 Rat
- Entrez Gene: 450078 Zebrafish
- Omim: 300256 Human
- SwissProt: O02691 Cow
- SwissProt: Q99714 Human
see all -
别名
- 17 beta hydroxysteroid dehydrogenase 10 antibody
- 17 beta hydroxysteroid dehydrogenase type 10 antibody
- 17-beta-HSD 10 antibody
see all
Anti-ERAB antibody 图像
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Western blot - ERAB antibody (ab87535)All lanes : Anti-ERAB antibody (ab87535) at 1/1000 dilution
Lane 1 : Jurkat cell lysate at 50 µg
Lane 2 : EC9706 cell lysate at 57 µg
Lane 3 : SGC cell lysate at 50 µg
Predicted band size : 27 kDa
Observed band size : 27 kDa
Anti-ERAB antibody (ab87535)参考文献
ab87535 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"