Anti-ER (phospho S104 + S106)抗体(ab118498)

概述

  • 产品名称Anti-ER (phospho S104 + S106)抗体
    参阅全部 ER 一抗
  • 描述
    兔多克隆抗体to ER (phospho S104 + S106)
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide surrounding pSer 104 and pSer 106 of Human ER conjugated to KLH.

  • 阳性对照
    • Human Tonsil

性能

应用

Our Abpromise guarantee covers the use of ab118498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 翻译后修饰Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
    Glycosylated; contains N-acetylglucosamine, probably O-linked.
    Ubiquitinated. Deubiquitinated by OTUB1.
    Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
    Palmitoylated (isoform 3). Not biotinylated (isoform 3).
  • 细胞定位Nucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ER alpha antibody
    • ER antibody
    • ER-alpha antibody
    • Era antibody
    • ESR antibody
    • ESR1 antibody
    • ESR1_HUMAN antibody
    • ESRA antibody
    • Estradiol receptor antibody
    • Estrogen receptor 1 antibody
    • Estrogen receptor alpha antibody
    • Estrogen receptor alpha delta 4*,5,6,7*/633 isoform antibody
    • Estrogen receptor alpha delta 6,7 isoform antibody
    • Estrogen receptor antibody
    • NR3A1 antibody
    • Nuclear receptor subfamily 3 group A member 1 antibody
    see all

Anti-ER (phospho S104 + S106) antibody 图像

  • ab118498 at 10 µg/ml staining ER in Human Tonsil by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-ER (phospho S104 + S106) antibody (ab118498)参考文献

ab118498 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118498.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"