概述

  • 产品名称Anti-ER抗体
    参阅全部 ER 一抗
  • 描述
    兔多克隆抗体to ER
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 245-273 of Human ER
    (NP_001116213.1, NP_000116.2, NP_001116214.1, NP_001116212.1,).

  • 阳性对照
    • MCF7 cell line lysate

性能

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应用

Our Abpromise guarantee covers the use of ab116716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 66 kDa.

靶标

  • 功能Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 翻译后修饰Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
    Glycosylated; contains N-acetylglucosamine, probably O-linked.
    Ubiquitinated. Deubiquitinated by OTUB1.
    Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
    Palmitoylated (isoform 3). Not biotinylated (isoform 3).
  • 细胞定位Nucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ER alpha antibody
    • ER antibody
    • ER-alpha antibody
    • Era antibody
    • ESR antibody
    • ESR1 antibody
    • ESR1_HUMAN antibody
    • ESRA antibody
    • Estradiol receptor antibody
    • Estrogen receptor 1 antibody
    • Estrogen receptor alpha antibody
    • Estrogen receptor alpha delta 4*,5,6,7*/633 isoform antibody
    • Estrogen receptor alpha delta 6,7 isoform antibody
    • Estrogen receptor antibody
    • NR3A1 antibody
    • Nuclear receptor subfamily 3 group A member 1 antibody
    see all

Anti-ER antibody 图像

  • Anti-ER antibody (ab116716) at 1/100 dilution + MCF7 cell line lysate at 35 µg

    Predicted band size : 66 kDa

Anti-ER antibody (ab116716)参考文献

ab116716 has not yet been referenced specifically in any publications.

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