All tags Epigenetics 组蛋白常见修饰及其位置列表

组蛋白常见修饰及其位置列表

组蛋白修饰标记基因组元件的速查表。

​​您有没有想过:“在哪里再次找到组蛋白修饰?是活性启动子还是增强子?”如果有这样的需求,我们已经为您归纳在本指南中,不必再返回文献中去寻找!

我们列出了最常见的组蛋白修饰和其标记的基因组区域,即您可以在 ChIP/ChIP seq 实验的哪些位置找到它们。另外,我们还列出了识别组蛋白修饰最具特异性的抗体。

Histone markWhere to find itAntibody
H3K4me1Active enhancersab176877
H3K4me3Promoters of active genes, bivalent domainsab8580
H3K9acActive enhancers and promotersab177177
H3K27acActive enhancers and promotersab177178
H3K36me3Transcribed regionsab9050
H3K79me2Transcribed regionsab177184
H3K9me3Heterochromatin, satellite repeats, gene-poor regionsab176916
H3K27me3Repressed promoters in gene-rich regions, developmental regulators, bivalent domainsab192985
Gamma H2A.XDNA double-strand breaksab81299
H3S10PWhole chromosomes in mitosisab177218
H4K16acReduced in cancer at repetitive sequences, active genes and enhancers in ESCs. Inhibits formation of high order chromatin structure.ab109463

绿色 = 通常具有转录活性区;红色 = 通常具有转录抑制区;灰色 = 其他功能。



参考文献:

  • 1. Greer, E. L. & Shi, Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat. Rev. Genet. 13, 343–57 (2012).
  • 2. Voigt, P., Tee, W.W., and Reinberg, D. A double take on bivalent promoters. Genes Dev. 27, 1318-1338 (2013).
  • 3. Barski, A., Cuddapah, S., Cui, K., Roh, T.Y., Schones, D.E., Wang, Z., Wei, G., Chepelev, I., and Zhao, K. High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837 (2007).
  • 4. Kim, J. & Kim, H. Recruitment and biological consequences of histone modification of H3K27me3 and H3K9me3. ILAR J. 53(3-4):232-9 (2012).
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