概述

  • 产品名称Anti-Ephrin B2抗体
    参阅全部 Ephrin B2 一抗
  • 描述
    兔多克隆抗体to Ephrin B2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic non-phosphopeptide derived from human Ephrin B2 around the phosphorylation site of tyrosine 316 (P-V-YP-I-V).

  • 阳性对照
    • HUVEC cells treated with Insulin or EGF.

性能

应用

Our Abpromise guarantee covers the use of ab75868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 37 kDa).

靶标

  • 功能Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
    (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
  • 组织特异性Lung and kidney.
  • 序列相似性Belongs to the ephrin family.
    Contains 1 ephrin RBD (ephrin receptor-binding) domain.
  • 翻译后修饰Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EFN B2 antibody
    • EFNB 2 antibody
    • Efnb2 antibody
    • EFNB2_HUMAN antibody
    • Eph related receptor tyrosine kinase ligand 5 antibody
    • EPH-related receptor tyrosine kinase ligand 5 antibody
    • ephrin B2 antibody
    • Ephrin-B2 antibody
    • EphrinB2 antibody
    • EPLG 5 antibody
    • EPLG5 antibody
    • Htk L antibody
    • HTK ligand antibody
    • HTK-L antibody
    • HTKL antibody
    • LERK 5 antibody
    • LERK-5 antibody
    • LERK5 antibody
    • Ligand of eph related kinase 5 antibody
    • MGC126226 antibody
    • MGC126227 antibody
    • MGC126228 antibody
    • OTTMUSP00000024973 antibody
    see all

Anti-Ephrin B2 antibody 图像

  • All lanes : Anti-Ephrin B2 antibody (ab75868) at 1/500 dilution

    Lane 1 : HUVEC cells, untreated with immunising peptide
    Lane 2 : HUVEC cells, treated with EGF
    Lane 3 : HUVEC cells, treated with Insulin


    Predicted band size : 37 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)

Anti-Ephrin B2 antibody (ab75868)参考文献

This product has been referenced in:
  • Ji YJ  et al. EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1. Nat Commun 5:3516 (2014). Read more (PubMed: 24662724) »
  • Moleirinho S  et al. Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts. PLoS One 8:e60028 (2013). WB ; Mouse . Read more (PubMed: 23593160) »

See all 2 Publications for this product

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