Anti-Ephrin B2抗体(ab7043)

概述

  • 产品名称Anti-Ephrin B2抗体
    参阅全部 Ephrin B2 一抗
  • 描述
    山羊多克隆抗体to Ephrin B2
  • 特异性The antibody will recognize recombinant mouse Ephrin-B2 by immunoblotting and ELISA. By immunoblotting and ELISA, the antibody shows approximately 50% cross-reactivity with recombinant human Ephrin-A5 and 15% cross-reactivity with mouse Ephrin-B1.
  • 经测试应用适用于: IHC-Fr, Indirect ELISA, WBmore details
    不适用于: ICC/IF
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Recombinant full length protein (Mouse). Expressed in NSO cells.

性能

应用

Our Abpromise guarantee covers the use of ab7043 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent dilution.
Indirect ELISA Use a concentration of 0.1 - 0.2 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml.
  • 应用说明Is unsuitable for ICC/IF.
  • 靶标

    • 功能Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
      (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
    • 组织特异性Lung and kidney.
    • 序列相似性Belongs to the ephrin family.
      Contains 1 ephrin RBD (ephrin receptor-binding) domain.
    • 翻译后修饰Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EFN B2 antibody
      • EFNB 2 antibody
      • Efnb2 antibody
      • EFNB2_HUMAN antibody
      • Eph related receptor tyrosine kinase ligand 5 antibody
      • EPH-related receptor tyrosine kinase ligand 5 antibody
      • ephrin B2 antibody
      • Ephrin-B2 antibody
      • EphrinB2 antibody
      • EPLG 5 antibody
      • EPLG5 antibody
      • Htk L antibody
      • HTK ligand antibody
      • HTK-L antibody
      • HTKL antibody
      • LERK 5 antibody
      • LERK-5 antibody
      • LERK5 antibody
      • Ligand of eph related kinase 5 antibody
      • MGC126226 antibody
      • MGC126227 antibody
      • MGC126228 antibody
      • OTTMUSP00000024973 antibody
      see all

    Anti-Ephrin B2 antibody (ab7043)参考文献

    ab7043 has not yet been referenced specifically in any publications.

    Product Wall

    We develop many of our antibodies in-house, while others are sourced from select suppliers with whom we have very strict non-disclosure agreements. This product falls into the latter category.

    This antibody has not been tested for cross-reactivity with human Ephrin B2

    The antibody should be useful in immunohistochemistry since it is a polyclonal raised against the whole molecule and therefore would recognise multiple epitopes. If you order and find that it does not work, in exchange for your negative data (which we ...

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    In general, antibodies raised against recombinant proteins give excellent IP results due to multiple and diverse epitopes. However, although it is likely to work, we do not yet have any data. Please let us know your results if you decide to use the ant...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"