Anti-Ephrin A1抗体[EPR1785(2)] (ab124911)


  • 产品名称Anti-Ephrin A1抗体[EPR1785(2)]
    参阅全部 Ephrin A1 一抗
  • 描述
    兔单克隆抗体[EPR1785(2)] to Ephrin A1
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide from the N terminal region of Human Ephrin A1.

  • 阳性对照
    • HUVEC (treated with TNF alpha), HUVEC (untreated) and MCF7 cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.




Our Abpromise guarantee covers the use of ab124911 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 24 kDa (predicted molecular weight: 24 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.
    • 组织特异性Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
    • 序列相似性Belongs to the ephrin family.
    • 翻译后修饰Undergo proteolysis by a metalloprotease to give rise to a soluble monomeric form.
    • 细胞定位Secreted and Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • B61 antibody
      • ECKLG antibody
      • EFL 1 antibody
      • EFL1 antibody
      • EFNA 1 antibody
      • Efna1 antibody
      • EFNA1_HUMAN antibody
      • EPH related receptor tyrosine kinase ligand 1 antibody
      • EPH-related receptor tyrosine kinase ligand 1 antibody
      • Ephrin-A1 antibody
      • Ephrin-A1, secreted form antibody
      • EphrinA1 antibody
      • EPLG 1 antibody
      • EPLG1 antibody
      • Immediate early response protein B61 antibody
      • LERK 1 antibody
      • LERK-1 antibody
      • LERK1 antibody
      • Ligand of eph related kinase 1 antibody
      • OTTHUMP00000033242 antibody
      • OTTHUMP00000033271 antibody
      • secreted form antibody
      • TNF alpha-induced protein 4 antibody
      • TNFAIP 4 antibody
      • TNFAIP4 antibody
      • Tumor necrosis factor alpha induced protein 4 antibody
      • Tumor necrosis factor alpha-induced protein 4 antibody
      see all

    Anti-Ephrin A1 antibody [EPR1785(2)] 图像

    • All lanes : Anti-Ephrin A1 antibody [EPR1785(2)] (ab124911) at 1/1000 dilution

      Lane 1 : HUVEC cell lysate, treated with TNF alpha
      Lane 2 : HUVEC cell lysate
      Lane 3 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 24 kDa
      Observed band size : 24 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-Ephrin A1 antibody [EPR1785(2)] (ab124911)参考文献

    ab124911 has not yet been referenced specifically in any publications.

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