Anti-Eph receptor B6抗体[RM0057-9B17] (ab73260)

概述

  • 产品名称Anti-Eph receptor B6抗体[RM0057-9B17]
    参阅全部 Eph receptor B6 一抗
  • 描述
    大鼠单克隆抗体[RM0057-9B17] to Eph receptor B6
  • 特异性ab73260 is specific for mouse Eph receptor B6. It does not cross-react with recombinant mouse EphA2, EphA3, EphA4, EphA6, EphA7 EphA8, EphB2, EphB3, and EphB4
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Recombinant mouse Eph receptor B6 extracellular domain

性能

应用

Our Abpromise guarantee covers the use of ab73260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/1000. Predicted molecular weight: 110 kDa.
IHC-P 1/50 - 1/200.

靶标

  • 功能Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
  • 组织特异性Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 结构域The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2.
  • 翻译后修饰Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
  • 细胞定位Secreted and Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EPH receptor B6 antibody
    • Ephb6 antibody
    • EPHB6_HUMAN antibody
    • Ephrin type B receptor 6 precursor antibody
    • Ephrin type-B receptor 6 antibody
    • HEP antibody
    • MGC129910 antibody
    • MGC129911 antibody
    • Tyrosine protein kinase defective receptor EPH 6 antibody
    • Tyrosine-protein kinase-defective receptor EPH-6 antibody
    see all

Anti-Eph receptor B6 antibody [RM0057-9B17] 图像

  • ab73260 at 1/200 dilution, staining Eph receptor B6 in LPS treated mouse kidney tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-Eph receptor B6 antibody [RM0057-9B17] (ab73260)参考文献

ab73260 has not yet been referenced specifically in any publications.

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