Anti-Eph receptor B2抗体(ab58592)

概述

  • 产品名称Anti-Eph receptor B2抗体
    参阅全部 Eph receptor B2 一抗
  • 描述
    山羊多克隆抗体to Eph receptor B2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Chicken, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    C-QKDRNHRPKFGQ

    , corresponding to internal sequence amino acids 864-875 of Human Eph receptor B2

  • 阳性对照
    • Human Lung and Placenta lysates.

性能

应用

Our Abpromise guarantee covers the use of ab58592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 117 kDa).

靶标

  • 功能Receptor for members of the ephrin-B family. Phosphorylates ARHGEF15, leading to its ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation. Can function in aspects of retinal ganglion cell axon guidance to the optic disk even when lacking its tyrosine kinase domain. Acts as a tumor suppressor.
  • 组织特异性Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
  • 疾病相关Defects in EPHB2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cek5 antibody
    • Developmentally regulated EPH related tyrosine kinase antibody
    • DRT antibody
    • EK5 antibody
    • ELK related protein tyrosine kinase antibody
    • Eph receptor B2 antibody
    • EPH tyrosine kinase 3 antibody
    • EPH-like kinase 5 antibody
    • EPHB2 antibody
    • EPHB2_HUMAN antibody
    • Ephrin type B receptor 2 antibody
    • Ephrin type-B receptor 2 antibody
    • EPHT 3 antibody
    • ERK antibody
    • ETECK antibody
    • hEK5 antibody
    • Nuk antibody
    • Prkm 5 antibody
    • Receptor protein tyrosine kinase HEK 5 antibody
    • Renal carcinoma antigen NY-REN-47 antibody
    • Sek 3 antibody
    • Tyro 5 antibody
    • Tyrosine protein kinase receptor CEK 5 antibody
    • Tyrosine protein kinase receptor EPH 3 antibody
    • Tyrosine protein kinase receptor QEK 5 antibody
    • Tyrosine-protein kinase receptor EPH-3 antibody
    • Tyrosine-protein kinase TYRO5 antibody
    see all

Anti-Eph receptor B2 antibody 图像

Anti-Eph receptor B2 antibody (ab58592)参考文献

ab58592 has not yet been referenced specifically in any publications.

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