Anti-Eph receptor A1抗体[MM0260- 8D36] (ab89471)


  • 产品名称Anti-Eph receptor A1抗体[MM0260- 8D36]
    参阅全部 Eph receptor A1 一抗
  • 描述
    小鼠单克隆抗体[MM0260- 8D36] to Eph receptor A1
  • 经测试应用适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human Eph receptor A1



Our Abpromise guarantee covers the use of ab89471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 108 kDa.
IHC-Fr 1/20 - 1/100.


  • 功能Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
  • 组织特异性Overexpressed in several carcinomas.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 1 Eph LBD (Eph ligand-binding) domain.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 翻译后修饰Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EPH antibody
    • EPH receptor A1 antibody
    • EPH tyrosine kinase 1 antibody
    • EPH tyrosine kinase antibody
    • Epha1 antibody
    • EPHA1_HUMAN antibody
    • Ephrin receptor Eph A1 antibody
    • Ephrin type A receptor 1 antibody
    • Ephrin type-A receptor 1 antibody
    • EPHT 1 antibody
    • EPHT antibody
    • EPHT1 antibody
    • Erythropoietin producing hepatoma amplified sequence antibody
    • Erythropoietin-producing hepatoma receptor antibody
    • Esk antibody
    • hEpha1 antibody
    • MGC163163 antibody
    • Oncogene EPH antibody
    • Soluble EPHA1 variant 1 antibody
    • Soluble EPHA1 variant 2 antibody
    • Tyrosine protein kinase receptor EPH antibody
    • Tyrosine-protein kinase receptor EPH antibody
    see all

Anti-Eph receptor A1 antibody [MM0260- 8D36] 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling Eph receptor A1 with ab89471. Tissue was treated with 15µg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

Anti-Eph receptor A1 antibody [MM0260- 8D36] (ab89471)参考文献

ab89471 has not yet been referenced specifically in any publications.

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