Anti-EPCR/CD201抗体[RCR-379] (ab81711)

概述

  • 产品名称Anti-EPCR/CD201抗体[RCR-379]
    参阅全部 EPCR/CD201 一抗
  • 描述
    大鼠单克隆抗体[RCR-379] to EPCR/CD201
  • 经测试应用适用于: IHC-Fr, Functional Studies, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tail base human EPCR positive RE1 cells

  • 常规说明


    ab81711 is useful for the inhibition of biological activity. The antibody inhibits thrombin dependent protein C activation and blocks APC mediated signalling.

性能

应用

Our Abpromise guarantee covers the use of ab81711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/10 - 1/50.
Functional Studies 1/5 - 1/50.
Flow Cyt 1/10 - 1/50. ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
  • 组织特异性Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
  • 翻译后修饰N-glycosylated.
    A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activated protein C receptor antibody
    • APC receptor antibody
    • APCR antibody
    • bA42O4.2 antibody
    • CCCA antibody
    • CCD41 antibody
    • CD201 antibody
    • CD201 antigen antibody
    • cell cycle, centrosome-associated protein antibody
    • Cell cycle, centrosome-associated protein antibody
    • centrocyclin antibody
    • Endothelial cell protein C receptor antibody
    • Endothelial protein C receptor antibody
    • EPCR antibody
    • EPCR_HUMAN antibody
    • MGC23024 antibody
    • PROCR antibody
    • Protein C receptor, endothelial antibody
    see all

Anti-EPCR/CD201 antibody [RCR-379] (ab81711)参考文献

This product has been referenced in:
  • Navarro S  et al. Association of the Thrombomodulin Gene c.1418C>T Polymorphism With Thrombomodulin Levels and With Venous Thrombosis Risk. Arterioscler Thromb Vasc Biol N/A:N/A (2013). Blocking ; Human . Read more (PubMed: 23520161) »

See 1 Publication for this product

Product Wall

Thanks for your email. I'm very sorry that even the replacement antibody still does not appear to be working as expected.

To help improve your results, Iam happy to provide a replacement of any primary antibody, credit or refund. Please let m...

Read More

Thank you very much for your interest in ab81711. FuncS refers to this antibody's ability to inhibit the biological activity of EPCR. Unfortunately, all of the data we have for this clone is currently available on the online datasheet.

Becau...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"