Anti-EPCR/CD201抗体[RCR-252] (ab81712)
Key features and details
- Rat monoclonal [RCR-252] to EPCR/CD201
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG1
概述
-
产品名称
Anti-EPCR/CD201抗体[RCR-252]
参阅全部 EPCR/CD201 一抗 -
描述
大鼠单克隆抗体[RCR-252] to EPCR/CD201 -
宿主
Rat -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus. This information is proprietary to Abcam and/or its suppliers.
-
表位
Antibody RCR-252 stains the extracellular domain of human EPCR. -
阳性对照
- Flow Cyt: HUVEC cells.
-
常规说明
Ablates APC binding to EPCR/CD201 thus blocking APC-mediated signalling.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituents: 0.1% BSA, PBS -
Concentration information loading...
-
纯度
Protein A purified -
纯化说明
0.2µM filtered -
Primary antibody说明
Ablates APC binding to EPCR/CD201 thus blocking APC-mediated signalling. -
克隆
单克隆 -
克隆编号
RCR-252 -
同种型
IgG1 -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab81712于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Flow Cyt |
1/50.
ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
说明 |
---|
Flow Cyt
1/50. ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
靶标
-
功能
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. -
组织特异性
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. -
翻译后修饰
N-glycosylated.
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. -
细胞定位
Membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 10544 Human
- Omim: 600646 Human
- SwissProt: Q9UNN8 Human
- Unigene: 647450 Human
-
别名
- Activated protein C receptor antibody
- APC receptor antibody
- APCR antibody
see all
图片
数据表及文件
-
Datasheet download
文献 (5)
ab81712 被引用在 5 文献中.
- Mutoh T et al. Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis. Nat Commun 11:1253 (2020). PubMed: 32152303
- Janssen A et al. ?d T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity. Cancer Immunol Res 8:530-543 (2020). PubMed: 32019779
- Healy LD et al. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem 292:8616-8629 (2017). PubMed: 28408624
- Dömötör E et al. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood 101:4797-801 (2003). Inhibition Assay ; Human . PubMed: 12586611
- Sturn DH et al. Expression and function of the endothelial protein C receptor in human neutrophils. Blood 102:1499-505 (2003). Flow Cyt ; Human . PubMed: 12714492