概述

  • 产品名称Anti-EPB41抗体
    参阅全部 EPB41 一抗
  • 描述
    兔多克隆抗体to EPB41
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 107 - 156 (EKGEGGQKEI EFGTSLDEEI ILKAPIAAPE PELKTDPSLD LHSLSSAETQ) of Human EPB41 (NP_976218; UniProt ID: P11171 isoform 5).

  • 阳性对照
    • Human fetal spleen lysate

性能

应用

Our Abpromise guarantee covers the use of ab98854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: for isoform 5, 87 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
  • 疾病相关Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
    Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
  • 序列相似性Contains 1 FERM domain.
  • 翻译后修饰Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
    Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
    O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
  • 细胞定位Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4.1R antibody
    • 41_HUMAN antibody
    • Band 4.1 antibody
    • E41P antibody
    • EL 1 antibody
    • EL1 antibody
    • EL1 gene antibody
    • Elliptocytosis 1 antibody
    • Elliptocytosis 1 RH linked antibody
    • EPB 4.1 antibody
    • EPB 41 antibody
    • EPB4.1 antibody
    • Epb41 antibody
    • Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked) antibody
    • Erythrocyte membrane protein band 4.1 antibody
    • Erythrocyte surface protein band 4.1 antibody
    • HE antibody
    • P4.1 antibody
    • Protein 4.1 antibody
    • Protein 4.1, red blood cell type antibody
    see all

Anti-EPB41 antibody 图像

  • Anti-EPB41 antibody (ab98854) at 1 µg/ml + Human fetal spleen lysate at 10 µg

    Predicted band size : for isoform 5, 87 kDa

Anti-EPB41 antibody (ab98854)参考文献

ab98854 has not yet been referenced specifically in any publications.

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