Anti-Ensconsin抗体(ab99259)

概述

  • 产品名称Anti-Ensconsin抗体
    参阅全部 Ensconsin 一抗
  • 描述
    兔多克隆抗体to Ensconsin
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 720-749 of Human Ensconsin (NP_003971.1).

  • 阳性对照
    • Colon Carcinoma, Ovarian Carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab99259 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Antigen retrieval is recommended. Antigen retrieval with citrate buffer will enhance staining. Likely to work with frozen sections.

靶标

  • 功能Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.
  • 组织特异性Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.
  • 序列相似性Belongs to the MAP7 family.
  • 翻译后修饰The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only phosphorylated on serine. Phosphorylated on threonine in mitosis.
  • 细胞定位Cytoplasm > perinuclear region. Basolateral cell membrane. Cytoplasm > cytoskeleton. Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP- 115)) antibody
    • E MAP 115 antibody
    • E-MAP-115 antibody
    • EMAP115 antibody
    • Ensconsin antibody
    • Epithelial microtubule associated protein of 115 kDa antibody
    • Epithelial microtubule-associated protein of 115 kDa antibody
    • MAP 7 antibody
    • MAP-7 antibody
    • Map7 antibody
    • MAP7_HUMAN antibody
    • Microtubule associated protein 7 antibody
    • Microtubule-associated protein 7 antibody
    see all

Anti-Ensconsin antibody 图像

  • ab99259 at 1/250 dilution staining Ensconsin in formalin-fixed, parrafin-embedded section of Human colon carcinoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.

Anti-Ensconsin antibody (ab99259)参考文献

ab99259 has not yet been referenced specifically in any publications.

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